Match # 45. November 28, 2021, 14:00. Sevastopol. SHC "Sevastopol"
FC "Sevastopol" – FC "TSK-Tavriya" (Simferopol)
Referee – Oleg Lapishko (Simferopol)
Assistants referee: Ernest Bekirov (Pervomaiskoe) and Dmitriy Domnikov (Simferopol)
Reserve referee – Aleksandr Kreshchik (Saky)
Inspector – Oleg Kochergin (Alushta)
Match # 46. November 28, 2021, 14:00. Bakhchysaray. Stadium "Druzhba"
FC "Kyzyltash" (Bakhchysaray) – FC "Yevpatoriya"
Referee – Dmitriy Ponomarenko (Dzhankoi)
Assistants referee: Oleg Mironov (Simferopol) and Sergey Vinokurov (Kerch)
Reserve referee – Denis Shudrik (Simferopol)
Inspector – Sergey Ogar (Sevastopol)
Match # 47. November 28, 2021, 14:00. Novopavlovka, Bakhchysaray district. SC "Skif"
FC "Gvardeets" (Skvortsovo) – FC "Rubin Yalta"
Referee – Roman Dovbnia (Simferopol)
Assistants referee: Roman Savitskiy (Simferopol) and Sergey Zhabchenko (Simferopol)
Reserve referee – Sergey Lysenko (Simferopol)
Inspector – Andrey Priimak (Simferopol)
Match # 48. November 28, 2021, 14:00. Alushta. TCAPRNT "Krymskiy"
FC "Aluston-SCC" (Alushta) – FC "Ocean" (Kerch)
Referee – Iurii Volkov (Simferopol)
Assistants referee: Vitaliy Pasternak (Simferopol) and Shevket Dzhaparov (Simferopol)
Reserve referee – Konstantin Popov (Simferopol)
Inspector – Vitaliy Viktorov (Simferopol)