September 15, 2021, 16:00. Bakhchysaray. Stadium "Druzhba"
FC "Kyzyltash" (Bakhchysaray) – FC "Ocean" (Kerch)
Referee – Oleg Lapishko (Simferopol)
Assistants referee: Roman Egorov (Sevastopol) and Denis Stetiukha (Sevastopol)
Reserve referee – Shevket Dzhaparov (Simferopol)
Inspector – Andrey Priimak (Simferopol)
September 15, 2021, 16:00. Novopavlovka, Bakhchysaray district. SC "Skif"
FC "Gvardeets" (Skvortsovo) – FC "TSK-Tavriya" (Simferopol)
Referee – Denis Shudrik (Simferopol)
Assistants referee: Aleksandr Plakhotniuk (Yevpatoriya) and Arsen Mamutov (Yevpatoriya)
Reserve referee – Iurii Volkov (Simferopol)
Inspector – Aleksandr Boitsan (Simferopol)
September 15, 2021, 16:00. Yevpatoriya. SC "Arena-Crimea"
FC "Yevpatoriya" – FC "Sevastopol"
Referee – Aleksandr Kreshchik (Saky)
Assistants referee: Konstantin Popov (Simferopol) and Vitaliy Pasternak (Simferopol)
Reserve referee – Dmitriy Karmanov (Frunze, Saky district)
Inspector – Vitaliy Viktorov (Simferopol)
September 15, 2021, 16:00. Alushta. TCAPRNT "Krymskiy"
FC "Aluston-SCC" (Alushta) – FC "Rubin Yalta"
Referee – Sergey Lysenko (Simferopol)
Assistants referee: Ekaterina Bibikova (Simferopol) and Maksim Strutskiy (Razdolnoe)
Reserve referee – Dmitriy Ponomarenko (Dzhankoi)
Inspector – Iurii Abramenko (Simferopol)